Support For Promising Scientists
nvestigations into prevention of brain cancer and
understanding the origins of our solar system have seen two
scientists from Waipapa Taumata Rau, University of Auckland
awarded prestigious fellowships.
The Royal Society Te
Apārangi’s Rutherford Foundation fellowships are awarded
annually to a select group of postdoctoral researchers, with
two of five fellowships going to Waipapa Taumata Rau
researchers this year. The fellowships provide a total of
$400,000 over two years to support the recipients’
research.
Preventing brain
cancers
Dr Akshata Anchan in the Faculty
of Medical and Health Sciences has been awarded a fellowship
for research titled ‘Melanoma suspension particles and
brain-metastatic extracellular vesicles in disruption of
brain endothelial barrier integrity’.
Brain cancers are
the most aggressive type of cancer, with devastating
prognoses. Though brain cancers can originate within the
brain, most are created by cancer cells travelling to the
brain from other body parts. This process is called cancer
brain metastasis, forming 'secondary' brain
tumours.
Brain metastasis likely occurs primarily through
the blood vessels. Transitioning across blood vessels to the
brain requires cancer cells to overcome the blood-brain
barrier, a biological ‘checkpoint’ defending the brain
against toxins within blood.
In this Rutherford
Foundation Postdoctoral Fellowship, Dr Anchan aims to
understand how brain metastasis occurs. She will investigate
how cancer cells infiltrate the blood-brain barrier using
patient-derived metastatic cancer cells, and how by-products
of cancer cells alter metastasis rates.
This research
programme may suggest interventions that can prevent brain
cancers from becoming established in the first place,
protecting patients in Aotearoa and the wider
world.
Discovering ‘small
worlds’
Dr Preeti Cowan in the Faculty of
Science has been awarded a fellowship for research titled
‘Discovering distant worlds in our solar system with deep
learning’.
Our stellar backyard is teeming with
‘small worlds’, remnants from the solar system’s
formation 4.6 billion years ago. Among the most distant of
these small worlds are the trans-Neptunian objects that
orbit the sun past Neptune.
These icy bodies are small
and hard to detect but can offer key insights into how
planetary systems form.
Large-scale astronomical
surveys use digital cameras on major telescopes to scan the
night sky for trans-Neptunian objects, producing several
terabytes of data. However, processing this data to detect
trans-Neptunian objects is a significant logistical
challenge – one that Dr Cowan plans to solve.
In this
Rutherford Foundation Postdoctoral Fellowship, Dr Cowan will
build and train machine-learning ‘neural network’ models
that can better detect faint trans-Neptunian objects in
large imaging datasets, including a survey with the
Canada-France-Hawaii Telescope.
Neural networks teach
computers to process data in a way inspired by the human
brain, with the potential for accuracy and performance to be
improved through training. These new models will
significantly lower the time and effort required to detect
trans-Neptunian objects, ultimately improving our
understanding of these important small
worlds.
Scholarships’ final
year
From 2024, MBIE will support future leaders
in research, science and innovation through the three Aotearoa
New Zealand Tāwhia te Mana Research Fellowships
schemes, which will replace the Rutherford Discovery,
Rutherford Foundation and James Cook Research
Fellowships.